Thank you for the information.
It isn't that I have that many buttons, but I was just thinking of future expansion to 8 buttons per player instead of just 6. To which I could leave those inputs open.
I think I am just going to use some of the extra locations for the admin buttons. I do appreciate your help though.
You do realize that for arcade games you don't even need six, D&D are the only games that use 4 buttons for Players 3 and 4. All others use 3 or less.
For console emulation (Nintendo 64, Dreamcast), you may well want 8 buttons per player, but IMHO, you would be better adding concealed front USB ports and plugging in gamepads for these games.