It depends on what you use.
If you use Plexi-glass, a.k.a. ACRYLIC, it could crack.
Acrylic is very brittle by nature, but is more resistant to scratching and a little clearer than Lexan.
If you use Lexan, a.k.a. POLY-CARBONATE, it will scratch easier, but be more flexible, and less prone to shattering.
I'm guessing you'll be OK, based on how much support there will be underneath, but wouldn't take any bets on it.