That depends on what you mean by "tailored" for the left-handed.
I've found that most left-handed people adapt readily to whatever is in front of them.
As far as a CP goes, you'll be best off with the stick on the left, buttons on the right.
That's how MOST controls are, and actually puts RIGHT-handed people at a disadvantage by requiring them to use their off-hand to control the character on screen.
If you can work in buttons to both sides, it will give people a choice; but, if not, I'd got sticks to the left.
I do prefer to use the trackball with my left hand, given a choice.
That is more a function of the button pushing than anything though.
I push buttons faster, and can push them for a longer period of time without getting worn out, by using my right hand.
As far as my overall control choices go, I WORK with the mouse in my right hand, so that I can push all the key combos with my left hand while using the mouse.
I PLAY with the mouse in my left hand, so that I can use the 10-key part of the keyboard for all the other controls because it is much more ergonomic than the key part of the keyboard.
(Buttons are in straight lines, the zero falls dead under your thumb naturally, etc....)