I have an Xbox in my cabinet, and both DOA and Tetris are 4 player games, as well as Shrek 2, which is a favorite of my kids.
Simpsons, X-Men, TMNT, and games of the like are all more comfortable with the angled sticks, but easily adaptable either way. Guantlet is not likely a game to ever be played on my cabinet, and even if it was, it is one that can still be played with the angled sticks without much issue.