Another thing to consider - what if your printer screws up the scale of your image, or if you've done the screwing up without knowing it - blam - either big fat white spots on your pretty CPO, or small all around, and your carefully thought out spacing between players is now uncomfortably in the "dude, quit touching me, I don't want to question if I'm gay" zone.
Plot out all your button/joy placeholders, put your plexi over it, open up yer holes, and AFTERWARDS, do the Xacto knife thing. You'll be thanking your lucky stars you took eye's tip on that one.