If it is for a newer Mac (Blue and White G3, All G4 and G5 Models, iBook, Powerbook G4, etc), it may work, depending if it can use generic drivers, or if that manufacturer also makes a PC Driver for it. A USB version will have the USB connector on that modern PCs use for perperials.
If it uses the older Apple ADB connector (found on Beige G3 down and earlier models down to the Macintosh SE, and the Apple IIgs), I beleive that those are not PC Compatible. An ADB device will have a 4-pin plug that looks like an S-Video plug on it.