I'm a 2-player kind of guy. No big panels here. I thought about trying two trackballs, but I don't think it would be worth it in my case. I don't really play anything other than Marble Madness where it would be useful. Here's what I'm thinking:
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I do all my toobin' with a fighter layout. I love that game.
What game uses multiple spinners? (besides Paige's classic

)
I'd go with driving controls, but besides off-road, all my racing is PC based. Nascar, Midtown, NFSU...