I am not sure if it is a problem with the rip fence slightly moving or the blade that is on the saw, or just the nature of the beast. I have had the saw for several years but mostly use it for repetative short cuts when making frames. I am using the general blade that came with the saw, so maybe that is part of the problem. I am concerend that when I got to rip the MDF for the cabinet that it will be a real problem.
You need to describe your saw a bit more, but from the sounds of it, I'm betting you have one of the ~$100 "table" saws, as that's a common problem with those and larger sheets of wood
without setting up an auxiliary table around it to support the wood AND the fence usually isn't as stable as those found on larger, more expensive saws. Changing the blade won't make your cuts straighter, but it
probably will make your cuts smoother if you pay for a decent 80T carbide toothed blade.
If you're worried about using your circ saw, fuggedaboudit. The 4 foot clamp I use won't work (probably) for your MDF, since it's width will be more than 4' and you need something for the longer stretch too...go get yourself an 8' lenght of angle iron, mebbe two if you want to cut the second one up for shorter saw guides. Clamp them to your workpiece (taking into account the space from the edge of the shoe and your blade) and just push the shoe up against it and saw away. When you're done cutting your pieces, mebbe you use your "saw guides" for added support in certain areas in your cab!
OH, and if you haven't already, change the sucky (usually) blade THAT came with. You'll probably LOVE a plywood or laminate blade, although you'll have to go slower than you would with the blade that you're used to.
If I'm wrong about your saw, and you paid a lot of money for it and it's a biggun, please forgive me, I'm guessing because there wasn't enough info on the saw. If it's a saw in the $200-400 range, you should have a Biesemeyer fence for that saw (or VERY similar copy) so go out and buy one...NOW!

Go prepared - get all those "it costs HOW MUCH for THAT THING?!?" thoughts outta yer mind, cuz their fences are well worth the money.
I'm intrigued, as I've never heard of a 10" circ saw. Is this an old thing, and where did you pick it up? That's gotta weigh a TON!
Good luck, you'll do just fine with your circ saw, patience, and your "saw guides".