Lexan (generic name: polycarbonate) is a little more expensive but not excessively so. I have always leaned towards Lexan because of it's resistance to cracking while being drilled or cut. Though it CAN crack, it is far less likely to do so than it's plexiglass (generic name: acrylic) cousin.
Other than that, it's a toss up. The two cut with similar tools. I used a standard table saw blade designed for wood to cut my 1/4 inch Lexan control panel cover. Plastic supply stores like TAP Plastics here on the west coast, USA, can sell you a higher tooth count blade that will cut it better and smoother but I had no problems with what I used. For the button holes, I used a 1-1/8 inch HOLESAW, not a "spoon", "paddle", or "speed bore" type bit. I am thinking using these types of bits on any plastic would be a disaster.
As others have counciled, sandwiching the plastic between two pieces of wood can ease the drilling of any plastic. Plexi is far less likely to crack that way. Another thing I have heard is to drill with the drill set to reverse so you actaully melt through. I've never done that but many swear by it. Use a drill press if you have access to one. It won't allow you to run the bit in reverse (drill presses don't have reverse), but it will give you nice clean straght holes that you can never get with a hand drill. It will also contact the surface of the plastic squarely which can help prevent the cracking some have experienced. If your drill has a variable speed trigger, try to start the cut on a slower speed and then increase speed. In any case, whetehr you have a variable trigger or not, ease into the start of the cut very slowly. A crack is often caused by the teeth of the bit sticking to the plastic it's trying to cut through or digging into only one side of a circle being cut and again sticking.
Hope this helps
Bumble