This was funny reading all the ideas you guys had to cut/drill plexi/lexan.
First of all you dont cut plexi with a knife, there is a special cutter like knife that is made just for cutting plastic glass, its probably not worth buying for most people because you will only use it one or two times. You can also use a jig saw, but your edges will need sanding as the saw frays it bad.
You can just snap the plexi in two but first you must make sure you have gone through atleast half way through the plexi/lexan first, just keep scoring the line and break it off the edge of a table so it breaks in one motion.
As for drilling i use antifreeze to keep the plastic from melting/cracking, and go slowly.