Okay,
Hoping additional information I'm putting here can help trigger someone how to get this thing to work. As mentioned, running Mamehook then running Mame 0.250 seems to do nothing.
Debug window is blank when I run MAME. Also, when I choose "Show Supported Devices" my PacDrive board doesn't show.
HOWEVER, I just ran a test in MH, in Test Mode I sent the command:
uls 1 1 %s%
and when I run it, it toggles the led bulb off and on so MAMEHooker can see the hardware and send commands for it to receive. I just don't know why just loading MH and running MAME does nothing.