I dabble with them occasionally, typically only for bulk text replacement or extraction, but never as part of a workflow solution. It's one of those tools I really would like to be more proficient at because they seem so versatile, but because I'm not using them every day I think I miss noticicing a lot of opportunities to use them and thereby learn them better.
I did use the RegEx find and replace in Notepad++ just a day ago to rip a list of links out of the Nasa Raw Images page for the InSight mission so I could wget a current set of the full mission images. I used
.*?((http(s?)

([/|.|\w|\s|-])*\.(?:png)+)
to capture any segment that looked like a link to a .png then replacement it with
$1\n
That gave me a nice list of URLs, where previously it was a single unbroken line of HTML that looked like this:
<li class="raw_image_container raw_image_container "><div class="raw_list_image" data-external-id="D000M0058_601662708EDR_F0000_0114M_"><div class="raw_list_image_inner"><a class="fancybox_slideshow" href="/raw_images/2854?site=insight" data-fancybox-group="images" data-fancybox-href="https://mars.nasa.gov/insight-raw-images/surface/sol/0058/idc/D000M0058_601662708EDR_F0000_0114M_.PNG" data-title="Sol 58: Instrument Deployment Camera (IDC)" data-sharedescription="" data-thumbnail="https://mars.nasa.gov/insight-raw-images/surface/sol/0058/idc/D000M0058_601662708EDR_F0000_0114M_.PNG" data-link="/raw_images/2854?site=insight" data-id="2854" data-external-id="D000M0058_601662708EDR_F0000_0114M_"></a><img src="https://mars.nasa.gov/insight-raw-images/surface/sol/0058/idc/D000M0058_601662708EDR_F0000_0114M_.PNG"></div></div></li><li class="raw_image_container raw_image_container "><div class="raw_list_image" data-external-id="C000M0056_601516832EDR_F0000_0461M_"><div class="raw_list_image_inner"><a class="fancybox_slideshow" href="/raw_images/3753?site=insight" data-fancybox-group="images" data-fancybox-href="https://mars.nasa.gov/insight-raw-images/surface/sol/0056/icc/C000M0056_601516832EDR_F0000_0461M_.PNG" data-title="Sol 56: Instrument Context Camera (ICC)" data-sharedescription="" data-thumbnail="https://mars.nasa.gov/insight-raw-images/surface/sol/0056/icc/C000M0056_601516832EDR_F0000_0461M_.PNG" data-link="/raw_images/3753?site=insight" data-id="3753" data-external-id="C000M0056_601516832EDR_F0000_0461M_"></a><img src="https://mars.nasa.gov/insight-raw-images/surface/sol/0056/icc/C000M0056_601516832EDR_F0000_0461M_.PNG"></div></div></li><li class="raw_image_container raw_image_container "><div class="raw_list_image" data-external-id="D050L0056_601516219EDR_F6262_0009M_"><div class="raw_list_image_inner"><a class="fancybox_slideshow" href="/raw_images/3771?site=insight" data-fancybox-group="images" data-fancybox-href="https://mars.nasa.gov/insight-raw-images/surface/sol/0056/idc/D050L0056_601516219EDR_F6262_0009M_.PNG" data-title="Sol 56: Instrument Deployment Camera (IDC)" data-sharedescription="" data-thumbnail="https://mars.nasa.gov/insight-raw-images/surface/sol/0056/idc/D050L0056_601516219EDR_F6262_0009M_.PNG" data-link="/raw_images/3771?site=insight" data-id="3771" data-external-id="D050L0056_601516219EDR_F6262_0009M_"></a><img src="https://mars.nasa.gov/insight-raw-images/surface/sol/0056/idc/D050L0056_601516219EDR_F6262_0009M_.PNG"></div></div></li>
Maybe someone should cook up an educational game where you learn RegEx by eliminating segments of text that drops down from the sky like Space Invaders... Or remove matching blocks of various colors of text to create matches like Candy Crush.