i think it depends on who will be using your cabinet. Shifted buttons are fine for you or me, but they can be difficult for other people who don't have an intimate knowledge of your cabinet. If you are going to be having kids or friends playing frequently, you'd be better off with another option. The coin reject buttons are a great choice. that is the way I went with my first cabinet, in addition to making the coin slots work as well. Reaching down to press the reject buttons makes it feel authentic. I found that while they worked great for adults, my kids had a difficult time reaching down to the coin door when sitting on a bar stool. So, what I did was add dedicated coin buttons to the front edge of the control panel box. this keeps the clutter off the top of the panel, but keeps them easily accessible.
on my 4 player cabinet, i skipped the coin door completely and just used the buttons on the front edge. nobody has any issues with it, it is easy to understand and no button combos are required, which is great for small children.