The only using 2 cores thing is no longer true, but only some drivers (the code for a specific arcade hardware) utilize more than 2.
Not sure about the driver for the Seattle hardware Blitz runs on.
Still in general the higher clock speed is better, but it does depend on the particular game you're trying to get to run full speed.
Have you tried reducing the original hardware resolution of NFL Blitz in MAME ? (IIRC it's a DIP switch setting)
That helps a good bit.
Also disable HLSL if it isn't already.
Might be enough to get it working without having to upgrade.
If you are going to buy another processor and you like 3D games, I'd go for the i7 because other emulators like Demul will utilize it.
(assuming the PC can also accept a modern video card)
That's my $.02