I replaced the touchscreen on my Megatouch XL with an ELO serial touchscreen.
It was plug and play.
I've also used a generic small (12"?) LCD serial touchscreen.
Back when I was building jukeboxes for my friends, the ELO USB touchscreens seemed to be going for around $80-90.
I've never used the overlays I see on ebay cheap, but I don't see why they wouldn't work.
With every one I've dealt with, the monitor and touchscreen use two different connections and show up as two different devices.
It varies by application whether or not they can be independently replaced though.
I imagine newer stuff is more integrated.
What are you trying to replace the touchscreen on?