How does the leaf adjustment work? Do you have to physically bend the leafs (leaves?) or do you loosen the screw and rotate the switch holder?
I'm a bit concerned because I've got a wood CP with 1 1/8" holes for the joysticks, and if I recall correctly, the joystick shafts are not perfectly centered in the holes. They're close, but not perfect. It never posed a problem with the Competitions, but I'm wondering if it will with these. And, if it does, if I will be able to make a small tweak to the switches to compensate.
The screws are not part of the adjustment. They help to mechanically fix the position of the switch holders, which are further secured by an adhesive. They should not be disturbed. Any required adjustments can be accomplished through slight bending of the leaves, and this should be done as close as possible to the body of the switch.
As to whether a slightly off center hole will affect anything, I'd say that depends on a few factors. First being, how far off is it? Absolute centering is usually not critical, if the shaft never comes into contact with the edges. However, if the hole is to be used as a throw limiter, which is perfectly acceptable to do with a wood panel, then it should be very close to centered. If it's only off 1/16" or thereabouts, one can ream out the mounting holes of the joystick base, which will increase the diameter by 1/8" to provide a bit of centering adjustment on the panel.
As with anything, installation methods will dictate the final result. How the Dominux is configured by the installer also has a substantial effect.
Long shaft=longer throw=more leverage=lighter resistance.
Short shaft=shorter throw=less leverage=higher resistance.
If the shorter throw is desired, but the panel is too thick, then the solution is to route a pocket in the underside for the stick, or in the case of a wood panel, reduce the size of the hole and use it for restriction.
Also of note, is that the throw of a leaf based stick is dictated by first, the physical restriction, and second by how far
you choose to push the stick while playing. If you have the switches adjusted to activate very close to the centered position, pushing the stick further than the activation point of the switch doesn't make them "more activated"

. This comes down to play style, and if you are used to using a microswitch based stick which doesn't have the ability to be tuned, and their switches activate at the far end of the travel, you may find that through a bit of adjustment in play style, a more comfortable and precise gaming experience is possible with a leaf based stick.