I know for sure some 64bit emulators won't run on 32 bit systems. Does MAME work outside of hyperspin?
Get the ipac software and remap your default keys. I mapped P1 UP, Down, Left and Right, as well as Enter and Esc to the corresponding keyboard keys, but for everything else I just assigned a letter starting at "a". I can't be bothered to shut off the stickykeys, or if CTRL works in NESTOPIA, etc. Mapping 4p is simple after that.
As I mentioned in your build thread, that screen is your game launch "fade". It can be shut off in hyperlaunch/rocketlauncher, you will have to google how to shut it off if you are using HyperHQ.