Welcome aboard, Tbone786.

The first thing to do is enable multimouse (change it from a 0 to a 1) in your mame.ini file.
If you can't find mame.ini, generate it by typing "mame.exe -cc" from the command prompt.
You won't need 3 OptiWiz's.
You can put one player on the X-axis and the second on the Y-axis of the first OptiWiz.
Then put the third player on the X-axis of the second OptiWiz.
BTW, when you order the second OptiWiz, be sure to select a different "USB Device Number" on the order page.
IDK if the RasPi will have the processing grunt to handle this game, but good luck.

Scott