That's a hard question to answer without knowing what types of games you're wanting to play.
Are you a fighter type player, or more of an 80's classics games type player.
This is a small single player panel I built to play the older games, like Toobin, Defender, RipOff, StarCastle, Asteroids and many others (see the attached file). The button layout gives me a lot of the old style control panel layouts, but allows me to play a lot of other classics. But as you can see, it really isn't much of a fighter style layout.
Good luck with your project.
TM