Ah, you mean how PLAYABLE would it be... that's a bit different than "will it work"...

Sorry, my misunderstanding.
Well, it's a 3.5" screen, and we're not talking retina display or anything, it's not gonna be anything amazing. But the Game Boy Advance was I think 240 x 160, and I had a less-than-officially-licensed multicart that I got in Thailand that was running some sort of multi-game emulator (NES maybe), and for old-school games like pacman and galaga etc. it was very playable. You could see some artifacts of the display being resized, it wasn't pixel perfect, but it was playable. This thing at 320 x 240 has twice the resolution. So... depends on what you want to use it for. If you wanted to play mostly old-school stuff on a 3.5" screen, I think it would be ok.