I have had the controllers in hand before, they will hook up via the usual analog methods. However those analog snap joystick baseball titles can often be had for a $100 bill in working condition, might just be easier to buy a real machine.
There are about a half dozen games that can use them, all golf and baseball titles.
I had a real machine briefly but enjoyed Clutch Hitter so much more than I flipped the World Series like 2 weeks later.