MaLa looks very cool and has lots of different layout options, I like that it supports animated layouts and plugins, etc.
However, I'm currently running mGalaxy as a front-end just because I wanted something super-simple, I only have two real requirements:
1) Show me a snap while I'm going through the game list
2) Play a random MP3 song while I'm choosing a game
mGalaxy works great, but I get the feeling that I'm missing out on some cool functionality by not using MaLa.
FWIW, I am using MAME 0.145, and will be using two u360 joysticks/6 button layout. My cabinet is not built yet, but I will have keyboard and mouse access once complete.