Cleanest way (and practically fool proof) is to drill the desired sized hole into a piece of wood as a template, then drill a pilot hole into your acrylic/lexan/plexi, then use your router and trim bit to widen that hole using the template.
^^ this
drill backward. it melts the plexiglass.
Not True. Ive managed to crack plexi drilling in reverse. The problem is that the drill isnt removing material when going backwards, and the buildup of material can harden and that cracks the plexi.
The main key to plexi:
1) Use a drill press, or a portable drill guide. Any variance or wobble can cause a crack.
2) Clamp the material. Any variance or wobble can cause a crack, so all sides much be clamped well. Use rubber / cloth to keep from marring the surface. Dont remove the plexi protective coating till the very end, when all work is done.
Yes. I wouldn't dream of drilling acrylic without a drill press and with a good work holding device. I have a 18mm MDF table top for my drill press with some moveable rubber footed toggle clamps. I can move them so that they clamp either size of the hole in question. You want to get as much clamping pressure on the job as possible to stop it from moving and minimise cracking.
3) Drill at maximum speed, BUT lower into the plexi very very very slowly. It should probably take +30 seconds per hole. The drill will heat the plexi.. melting it, as the blades then clear out the melted material. If you go too deep too quickly, the plexi is too rigid and can crack easily.
I have always drilled all of my holes in acrylic at <300RPM. They cut the material nicely without melting and don't leave any kind of nasty melted edge.
4) As posted, a smaller diameter starter pilot hole will help. Smaller diameter holes have much less tendency to crack the plexi. You could even use like 3 passes using 3 different bit sizes if you wanted to.
Yes this is a good tip. However, bear in mind that if you are using a forstener or spade bit you need to make sure you leave enough material in the scrap piece below the acrylic for the center point of the next drill.
When drilling smaller holes standard jobber bits you can still crack the acrylic even when using a bench drill and a good work holding device if you try to feed the drill to fast. Acrylic and Polycarbonate (Lexan) are both relatively soft and if you wanted to you could drill through the thicker pieces fairly fast. Its the speed of the drill as it exits the work piece that is the important part. If you feed the drill too fast as it exits the hole it will grab the material and pull the drill through the last couple of millimetres. It is this increase of feed as well as the lead angle on the drill that will crack the material.
You need to pay attention and keep an eye on when the drill is going to exit the material, obviously with thinner sheets this will be almost instantly. As the drill exits you need to make sure that you are feeding it slowly and at a controlled rate so that the drill isn't allowed to grab and pull its way though. A piece of scrap MDF etc below it is an absolute must as it supports the material around the hole as the drill exits.
90% of the time when cutting large (1/2"+) holes in acrylic I route them to size using a template. To drill the relief hole for the router bit i first drill a ~5mm drill for the pilot hole. I then use a 1/2" metal working slot drill. Slot drills have 0 degree lead on them and nicely cut though the material. Since they have no lead on them they tend not to crack the material as they break through as the whole cutter face breaks though at the same time.
This 1/2" hole allows me to get my roughing bit in. I use a 3/8" flush trim bit but with a 1/2" bearing on it. If I run this round the profile of the hole/profile etc it follows the profile exactly but will leave an even 1/16" of material on for finishing which I then remove with a 1/2" flush trim bit.
6) Use a test scrap piece to practice.
Yes, if you are not used to drilling holes in acrylic etc then you really should practice in some scrap pieces. You don't want to ruin a large expensive piece of material on your first go.
7) Lexan is much easier to cut holes in, however, the surface of lexan will scratch much easier, so when people play on your panel, they will scratch the heck out of it.. most esp if they wear any watches, jewelry, etc.
Yes, Polycarbonate is slightly easier to cut but it will scratch much easier. To be honest acrylic is very easy to cut and its an awesome material to work with.
IMO lexan should never be used for CPOs