It could be System Specific, not sure what setup you have but I run NullDC without problems on the following spec (albeit on GameEx);
Intel 8400 cpu
Radeon HD4870x2 gpu
Vista 64-bit
4Gb Ram
I've attached my NullDC.cfg file.
The command line I use for NullDC in GameEx is as follows;
nullDC_Win32_Release-NoTrace.exe -config ImageReader:DefaultImage="[ROMPATH]\[ROMFILE]"
I would of thought this will be different for you using HyperSpin, and would probably also depend on if your using Hyperlaunch, but the Parameters should be similar if not the same.
Maybe someone could chip in with an exact command line to run NullDC on HyperSpin...
