Windows & dos supports multiple mice.
You can have one PS2 & two serial & several usb if you like.
They will all operate at the same time but they all control the same cursor.
So if you spin the Tb in one direction & the spinner in another, the cursor will simply jitter & then go in one direction when the other input stops spinning.
Right now I have three different pointing devices attached to my PC.
A usb cordless mouse, a PS2 imperial trackball, & a usb optical mouse, & sometimes I attach a serial spinner.
Makes sense???
As far as having two seperate TBs & have them operated independantly in mame, I think that Analog Mame may support this but I'm not sure how.
Good luck!