Yeah.
I set it up playing Metal Slug 5, and then set it as the default. But using MS as the example.
I set A, B, C to SW1, SW2, and SW3, and those are still the IPac defaults, but SW1, and SW2 are also wired up to a SpinTrak to act as mouse buttons.
This set up so far has worked with my other 15+ emulators just fine, but WinKawaks by itself, and also in MA have issues. Out of MA the left mouse button doesnt harm the game, but the right button pauses the game. In MA both buttons cause WK to minimize (right click makes it pause and minimize) and I have to alttab back.