I have no trouble with my U360 in Daphne.
It's not a problem if you have ONE joystick and all your "exit" and "coin" buttons are mapped to that one joystick. But the way I have my panel set up, admin functions (like pause) are mapped to the second player buttons. And the kicker, my EXIT button (a small little unassuming Radio Shack button in the upper right) is wired to Mouse 2 (the only available input when I added that button at the 11th hour).
I aim to keep my cabinet as simple as possible for guests, and Daphne games complicate it too much when I have to have workarounds in place. And at the end of the day, I could do things differently, but I'm not totally in love with DL or SA enough to go through the trouble.
(P.S. - Not Daphne's fault, most of the the LD games didn't have need for much configuration - save for that multi-button game Thayer's Quest. Not expecting them to change the entire program for the small number of people who have limitations such as mine. It just is what it is.)