Today my work computer was all crudded up with malware. Not sure how, as this sight is probably the most questionable of the sites I access with it. We deploy McAfee, but the crap gave it the slip. Anyway, spent half the day battling it, and while I'm not a real IT person, I'm the closest thing our company has in-house. I think I beat it and here were the tools:
First downloaded Malwarebytes and ran it. It found 5 instances and terminated them, thought I was in the clear. Scanned it with MB again, then scanned it with McAfee...nothing.
Then, every now and then a random IE window would open with a Lycos search in it. So I tried GMER, which crashed my computer at a different point in the scan 5 times.
Then I downloaded tdskiller and ran it. Took all of 15 seconds and found and eliminated the critter. So far, so good...knock on wood.
So I hope this helps if you get crudded up any time soon.
