For big stuff, I'm a fan of Altium Designer. It's way better than PADS, in my opinion, and doesn't cost any more. In fact, the "everything" version of Designer is cheaper than the "everything" license to PADS. OrCAD is alright, but it's definitely showing its age, and it's also not cheap, though it is usually cheaper than Designer and PADS.
For little stuff, Eagle is likely your only option unless you want to blow tons of cash. Many board houses have their own software, but they usually have limited export capabilities. The 4PCB (Advanced Circuits) software called "PCB Artist" will let you export to standard formats (including RS-274X and Excellon) once you place an order for that part number through 4PCB. I'm told it's decent software, too.
If anybody wants something done, I'm more than happy to do it. I've got access to professional CAD software, but I'm unemployed, so looking for any work I can get. I've done stuff ranging from tiny (2x3" 1 layer PCB for a very simple power supply) to monsters (4x6" 8 layer with BGAs and leadless parts galore and high-speed signals).