Yes. Hardly ever happens, however, as most of the time the CHD is complete (since it's essentially an image of a whole drive or CD - it's an all or nothing situation). The only one in recent memory that changed was in case of CARNEVIL (in 0.128u6), that recently got a new confirmed dump and the previous CHD that *WAS* named CARNEVIL got moved to a clone set, CARNEVI1. Since the actual rom chips are the same in the two CHD's - you should be able to simply rename the pre-0.128u6 CARNEVIL.CHD to CARNEVI1.CHD and run that as before.