Memeo made a program that would synchronize folders over the network. I can't remember what it was called, but it came with an old Maxtor OneTouch external hard drive I bought a long time ago. I don't see the program on their website now.
Anyway, it wasn't strictly a backup program. After the initial backup, files were only copied over that had been changed and the copy took place immediately, not at some predesignated time. It constantly monitored the specified folders and instantly synchronized the folders across the network, so your data always stays secure. A really cool feature of it, though, is that you could specify how many versions of a file you wanted to keep. So, for example, if you told it to synchronize your My Documents folder with 5 versions, it wouldn't just keep a backup, but it would let you access any of the past 5 changes. This is super useful for those times when you don't realize that there's a problem -- say, an important file went corrupt -- until long after you've replaced your good backup with the corrupt one. Of course, this means that the program is constantly running in the background, but the little bastard was pretty much invisible. It didn't use any appreciable amount of resources.
At any rate, I didn't have any use for it at the time, so didn't use it enough to vouch for its stability. But what I saw seemed pretty cool.