This is a long-shot but does any of you use Reason 2.5 and an M-Audio device like the Ozone?
It's supposed to be more or less configured for Reason "out of the box" but when using the Redrum drum machine, the keyboard triggers "mute" instead of the actual sound trigger (whole lot of good that does). Using the remapping option in Reason, mapping to the trigger button is NOT an available option.
Any ideas?