I think as far as ease of configuration maximusarcade, its super easy. Its also pretty easy on the eyes but it takes a while to load(I realise most of you just boot into your frontend and call it good we run a media center) and it takes a bit to come back up after exiting a game.
MaLa I think is pretty nice and easy to use also but not quite as easy as maximusarcade, and it has a fault that really hurts it in my book. It doesn't support true transparent png's it actually has trouble with png's period, I have to export my pngs from illustrator to get them not to error. Any png saved from photoshop doesn't work for me. I also wish it had a bit better text list, when you are at the beginning or end of a text list it leaves the top or bottom of the text list empty creating a funny looking text list. Besides those two things though it does work really well and is pretty sold. Lots of options and plugin support. It runs fairly light too, starts up quick and such. I so wish it had true transparent png support that would put it over the top I think.
hyperspin is very nice though. It has alot of promise. Its still in beta but already it works really well on my system. Its wheel based and supports all sorts of animations. You can set up individualised animations for every single game if you want/have time/and or someone has already made it. And its easy to setup those animations with a few lines in an xml file. I would keep an eye out for it. I think it won't be too long till its released as its already pretty strong. Just needs a backend and some more artwork, plus a few features here and there. You can find a video showing it in action somewhere on this forum. It really does work the way that video shows.