Are you using the same version of Mame that you were using on the p3?
Have you checked all the tasks running in teh background and disabled any not required?
Same for services - disable or set to manual startup all services not required (per Black Viper or other).
When running Mame, check all tasks(processes) and their memory usage, and the performace tab
in the task manager will tell you how much cpu and ram/memory usage is going on.
Just read another post where heat was causing the slowdown.
Run coretemp or other, check to see if your processor's running hot. Maybe you need to blow all the dust off your
heatsink/fan and/or clean off and reapply some Arctic Silver5 or other thermal paste. If things are dusty, good time to
clean out your power supply and other fans too.
edit: added check cpu heat, etc