Probably not, at least not without stripping the internals and replacing them with technology similar to those found in PC light guns, as old zappers like the NES one work by sensing the light emitted by a CRT screen.
As far as my knowledge goes, PC lightguns use sensor bars to map a screen size, then detect the gun's position within that 'frame' and feed it back to the PC.
I'd love someone to tell me otherwise though, as the Zapper is a symbol of the classic age.
At very least, it should be easy to rip out and swap out parts with the LCDtopgun or similar...