One sided has the nice smooth "paper" face on one side, two sided... you get the idea. It is a fantastic produt to use for a cabinet. It has the smoothness of MDF with a plywood core. It also is made using weather resistant materials, so water doesn't turn it to mush so quickly like MDF.
Like plywood, you should look to see that the sheets aren't warped or only 5-ply. Good MDO will be at least 7 or more plys with minimum voids, and flat.