I don't use anything but do have experience with video compression and the like, so what I say is based on that rather than DivX or AutoGK specifically.
The first big factor is going to be stuff like special features, which audio portions you keep, and to a small extent subtitles.
Are you just going with the usual full movie, 5.1 and 2 channel stereo? Does DivX support DVD menu style functionality for including the special features or is it straight video/audio?