Hey Dave! Great program, thanks. 
I am using NTFS w/ XP Pro on both my PCs. Perhaps the game launcher directory is nested too far in a directory tree or a long file named dir is in GL's path. I use XP alot and sometimes stupid errors with all sorts of programs get fixed when I move them into a dir with intentional short names (for folders). DVD2SVCD is one that comes to mind...
Yeah, give that a shot. Maybe spaces in the full path are an issue, too?
Since I know you'll be reading this, There are two issues that I have not figured out yet.
Well, I don't read this message board that much any more. For quicker response, post to the Game Launcher mailing list.
a) How do I get rid of the grey border around screenshots?
GL does not add any grey border. The screen shot must already have the border in it. Try viewing the screen shot in an image viewer.
b) More than 16 emulators won't work with GL. Any way to support more than this? I use mame catergories as each "emulator" but that also means I have no room to add a genesis or snes emu.
Unfortunately, 16 is the limit in the current version, sorry.
-Dave