Thanks for the quick response "brownshow". I have messed with the volume in MAME, but I have noticed that even with the volume turned all the way down you can still hear some sound, but more importantly using the volume is not a 1 button solution which is what I am looking for.
I have experimented with the ArcadeFX front end and I have noticed that you can turn the sound off completely using the admin controls and this only mutes MAME and not my juke box. This is what I am looking for, but I would prefer to be able to activate the mute feature from within an active game with a single button.
An acceptable solution would be to activate mute with a single button from within the front end. Since ArcadeFx is able to mute MAME I am sure that this function can be applied to other front ends as well.
By the way, if anyone is interested, I can post a simple AHK script that I wrote which will allow you to assign a single button that will switch between your jukebox program and your currently active game or if a game is not active between your jukebox program and your front end.