That's not necessarily the case RayB. I often find that I can add to the aesthetics by scaling up... you just have to understand your medium. I often draw very tiny drawings with a grease pencil and scale them up by hunreds of percents, and they look fantastic.
Generally this could be true, especially if you are working with markers, or some other type of drawing utensil that leaves marks (colored pencils, crayons, etc) Pastel, watercolor and other soft mediums can greatly benefit from being scaled up.