4 player CTRL+ALT+DEL triggered

[00nerdzo]

I would like to keep my configuration the way that it is that way i do not have to go through the entire Rom pack and configure all my games.
That being said, When I am playing ninja turtles and leo decides to do his special and raph jumps, this triggers a (button 1 player 1 = left ctrl) + (button 2 player 1 = left alt) + (player 4 num delete button) = lock screen in windows 7...
if I start a game in and go to general input and change it around say to like num 1 to change player 4's button 2 option, it works, however once I exit the program. it doesn't save. If i change the input for "This Game" it works, So i have to do this every time I use a different game.
I cannot find the config/ini file to change this. am I missing something. I would rather not turn off ctrl alt del as it is a pretty vital function to windows. what are some solutions you guys have come up with?