For MAME? Probably not. For PC type games, probably. Maybe, I dunno, I only play 30 year old games on my cab.
I don't know because I search other forums and they have good things to say about it Example of a user:
MAME can take advantage of this resolution, because when you use an HLSL or GLSL shader to simulate a CRT, you actually need that many pixels to do a good shadowmask simulation as well as even scanlines. It also gives you enough pixels to do good scanlines and a good shadowmask for medium resolution games, which looks amazing.
other user:
Similarly the HLSL shader I mentioned works better the higher resolution you go because at very high resolution (like 4K) an LCD can begin to simulate the shadow mask of an old CRT tube.
We have the technology but sadly the requirements of these old games don't mesh all that well with the new standards that that market has settled on. However with more LCD manufacturers waking up to the fact that console and PC gamers want low lag, and and LCD technology continually improves resolution and refresh rate we might actually solve most of these problems in the future....