Few things to point out, and then my opinion:
USB Keyboard is very different than USB mouse or USB joystick.
Just because something works one dirrection doesn't mean it will work the other.
Lightguns can be seen by the PC as either a mouse, or an analog joystick.
Same on the PS2. (currently mouse is the best way in a PC, but I don't know about PS2.)
Usually a mouse driver won't work on a joystick, and vis versa. Are you sure the lightgun is a
mouse to a PS2, or is it a joystick? (see next point, too)
Add to that, PS1 & 2 seem to have four different lightgun "standards": at least the lightguns I looked at this weekend had four position switches: PS1, PS2, Guncon1, Guncon2. (BTW, can anyone in the know describe the differences, or point me to a link, between the guncons and normal PS2 data formats?)
There are "USB" mice (and other devices) that work in windows but not Macs, and vis versa.
At least one playstation2 lightgun
can be used on a VGA monitor (with upscanned signal). Does not say anything about on a PC, though.
IIRC, there was all this hype on the PS2 being USB compatable, and then a small article saying the PS2 is
close to the USB standard but is having problems, and then a small blurb on PS2 not being close enough to be called "USB compliant", and then nothing at all. (And keyboards working does not prove it is totally "USB compliant")
There is the option of moving the actlab lightgun sensor into a different case. Hard part, of course, is securing the lens & sensor, then lining up the lens/sensor with the new case's sights, and finally fitting the circuits in the new case.

IMO, the biggest thing to worry about is:
"What is the lightgun to a playstation: a mouse, or a joystick, or a combo or something else."
And the immediate followups,
"What USB ID (if any) do the lightguns use, so drivers can be setup or if needed written?", and
"Is there already a win driver that can work with this?"
Then again, I might be just thinking in the box.