I only run Mame, Impact, Modeler, and U64emu on it, it's currently in my cabinet. As far as I've read, Ipac works fine under W2k/XP, it's the programming utility that isn't. I use the mame preset on it anyway, so that's not an important thing to me. I've been thinking of running a few PC games on it like MK4 or Golden Tee, but I haven't gotten around to buying them yet.
DMA