Unfortunately I don't think there is. I have never seen an option for it. Also, disabling that would prevent most users from using keyboard shortcuts, and prevent windows from being used without a mouse (or with a broken / crashed / unresponsive mouse), so I'm pretty sure Microsoft wouldn't have included it as a feature.
If you problem involves a pushbutton assignment on your control panel, I suggest you remap buttons because there are all kinds of fun little nasty windows things that happen if you get certain combinations of players in a game together.