Not personally, but I work with a guy who is. I considered it, but I know I won't complete it so I'm not about to start. (A matter of knowing me) I understand 6 years is a fast time to complete one, assuming you don't slack off building it, and have normal commitments. Considering the station of avation, some have estimated that most of the airplanes finished this year will be home builts.
The famious Oskosh air show is all about planes people build themselves.
In short, it is done all the time, and if your planes are good, and you do it right, it is just as safe as any other airplane. I wouldn't hesitate to fly in any such plane that passed all the certification, but I wouldn't want to be near the first test runs.
Mame cabinets are more interesting to me - at least now. I also consider it reasonable to belive I could finish a cabinet before I got bored and moved on.