I'm new to this myself, but as I've had some great support on this forum, I'd like to give a little back where I can....
In the MAME folder, there's a config folder, check there's not a mame.ini file in there overriding the one in the main folder.
Also, I'd try disabling HyperLaunch and see if that helps. HyperSpin is just a frontend, it's not doing anything - unless you've put some command lines on the wheel setup.
Another thing to check, HyperSpin uses some Adobe plugin, and that limits the number of resolutions you can have. Go into VMMAKER.ini and change the total to 90 (I think it's 120 or 200 by default), run it again, reboot, and try HyperSpin now.