I picked up a PC version and have played for about 2 hours. My PC has what I guess is an older video card, a Radeon 4850 that's lasted well (for me) for a few years now. I'm playing at high resolution which is what the game decided I should run at on an LCD 19something x1050i think which is what I have.
I have no problems, there aren't any bugs I care about so far, and frankly I think there's almost too much eye candy for me. As with all games it takes me a little while to adjust to the controls and get to the vibe - like every video game, right?
Once I get a handle on the interface I hope and guess I'll pour an embarrassing number of hours in to it over the next few years. I really enjoyed Oblivion, Fallout 3 and Fallout NV, so I'm guessing this new engine will carry it's weight.