Lori is an annoying ---smurfette---, but at least you care about her. In the comic, she isn't a standalone character, she is just Rick's woman. The whole her trying to terminate the preganancy isn't in the comic, the whole interaction with shane, and how she has been sort of standing up to Rick on the show, isn't in the comic. Her character on the show is much more interesting.
I am on the fence about whether I like show Dale or comic Dale better. I think offing him early will make Andrea more interesting in the end. I never liked him much in the comic, though with him gone, they are missing out on the cannibals thing, though, really, they can run that story with any other peripheral character. The most interesting thing about Dale is that he got bit and lived, and agian, they can do that same thing with other characters.
You don't really have to tone down the governor much, I imagine the fights are still there, he still has a zombie little girl, he's still psycho. The only thing that will probably be different is the rape of Michone, he probably tortures her, and doesn't rape her, I am guessing, and her payback probably won't be as graphic.