Oh yeah, disable flash (use an add-on that will selectively allow you to re-enable it if you absolutely must have it - note that Youtube is generally usable with HTML5 video, now), don't install any PDF plugins for your browser (instead open it in a separate window after confirming that you actually want it in the first place), remove the stupid Java plugin that you don't need, etc.
In general, don't let Adobe touch your web browser

I don't have ANY of those installed, and I don't really miss them, especially now that Youtube is usable so I can watch the silly cat videos people insist I absolutely must watch. No need to run a 64-bit browser (are any other than IE popularly distributed for Windows?), but it doesn't really hurt, and it probably would break some actual browser bug exploits that haven't been specially tweaked for the 64-bit version.
If you could possibly manage to keep all those plug-ins and crap up to date, it might not be a big deal, but many of those vendors are not known for quick response to security problems, and the fact that each and every one of them has some convoluted update process that may or not be partially automatic makes that almost impossible. Even IE is pretty decent, these days, but the popular plug-ins are awful. That's probably why Microsoft is apparently trying to get rid of them for Windows 8's Tablet oriented usages.
All the major browsers are pretty good about warning you if you're intentionally initiating an action that could be an infection vector, such as installing plugins, running executables, etc., barring unpatched security issues of course. Flash, Adobe Reader, Java, etc....not so much.